Bringing structure visualization capabilities to the MINERVA platform. Right click on any node representing a protein, to bring up the context menu via which you can access MolArt.
An online resource developed at the Stanley Center in the Broad Institute of MIT and Harvard. The goal of MISCAST is to interpret single amino-acid-altering missense variants on protein 3-dimensional structure and to thereby forcast their biological impact. MolArt facilitates visualization of pathogenic and population variants and contrast them with a plethora of structure-derived features.
The Nullomers Database is a web-based resource which aims to facilitate exploration of biological nullomers (a.k.a. minimal absent words). Its purpose is to catalogue and share statistically significant non-occurring sequences which are unexpectedly absent in several genomes and proteomes.
The Annotation, Visualization and Impact Analysis (AVIA) is a web application combining multiple features to annotate and visualize genomic variant data. Users can investigate functional significance of their genetic alterations across samples, genes, and pathways. For molecules with 3D information available, MolArt supports the 3D structure visualization.
MRMAssayDB is an integrated resource for targeted proteomics assays. The Web-based application maps and links the assays from the repositories, includes comprehensive up-to-date protein and sequence annotations, and provides multiple visualization options on the peptide and protein level. It contains a visualization module for coupled molecular structural annotation browsing allows the user to interactively examine peptide sequence and any known PTMs and disease mutations, and map all to available protein 3D structures (MolArt).
A single-page example showcasing the plugin on the example of Alpha-synuclein, a protein which accumulates in the brain cells of patients with Parkinson's disease. The mapped structure with PDB ID 2N0A nicely shows the fibrils. Similar structure can be also seen in tau protein in Alzheimer's disease.